| Abstract High pressure homogenization method was used to prepare Nimesulide loaded nanostructured lipid nanoparticles (NLC). Single factor design was chosen to study the influence of solid-liquid lipid ratio, amount of lipid, amount of emulsifier, drug-lipid ratio, homogenization pressure and homogenization cycles on quality of the prepared nanoparticles. Orthogonal design was used to optimize the preparation parameters. The optimal preparation method was 3:10 of oleic acid glycerin monostearate(GMS) ratio, 1:40 of drug-lipid ratio, 1.4 g of TPGS, 90 MPa of homogenization pressure. Particle size and entrapment efficiency of NLC prepared by optimal conditions were 132.6±1.4 nm and 82.35±1.23%, respectively. The scanning electron microscope showed that the nanoparticles were of spherical shape. The in vitro release study showed that release behavior accorded with Higuchi model. |
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2014, Vol. 31 
