Abstract The effectiveness of eucalyptus oil microemulsion in transdermal drug delivery system was evaluated. Felodipine was used as model drug. Nine o/w microemulsion formulations were prepared using oleic acid, IPM and eucalyptus oil as oil phases respectively. The physicochemical parameters were measured and skin permeation experiment in vitro was investigated. The drug loading, permeation rate and lag time were compared and optimized formulation was composed of eucalyptus oil (5%, w/w), Tween 80 (27.5%, w/w), ethanol (27.5%, w/w) and water (40%, w/w). And the skin irritation study was performed using the optimized formulation. The eucalyptus oil showed high emulsification capacity, high solubility of lipophilic drugs, high permeation enhancement effect and good stability. However, eucalyptus oil possessed a certain skin irritation, so it should not be excessive.
QIU Shao-Feng, LI De-Xin, WEI Zhen-Ping.Evaluation of Microemulsion Using Eucalyptus Oil in Transdermal Drug Delivery System[J] Chemcial Industry and Engineering, 2013,V30(3): 44-49
2013, Vol. 30 
