Synthesis of Isopropyl Chloroacetate with Composite Catalysts
GAO Xiao-Han1, GAO Jun1, ZHANG Hong-Feng1, LIN Li2
1 College of Chemical and Environmental Engineering, Shandong University of Science and Technology; 2 College of Chemistry and Chemical Engineering, Shandong University
Abstract Isopropyl chloroacetate was synthesized from chloroacetic acid and isopropyl alcohol with Ce(SO4)2·4H2O/KHSO4 as a composite catalyst. Effects of different cocatalysts and the ratio and amount of catalysts on the reaction were considered. The molar ratio of isopropyl alcohol to chloroacetic acid, the reaction time and the amount of catalysts were optimized, and the repeatability of the composite catalyst was checked. The experimental results show that better catalytic efficiency can be obtained by the composite catalyst of Ce(SO4)2·4H2O/KHSO4. The optimized synthesis conditions were determined. The molar ratio of isopropyl alcohol to chloroacetic acid is 1.35∶1, m(Ce(SO4)2·4H2O)/m(KHSO4) is 2, the amount of catalyst is 1.1% (molar percentage), the reaction time is 3 h, in which the yield is 92.1%.
GAO Xiao-Han, GAO Jun, ZHANG Hong-Feng, LIN Li.Synthesis of Isopropyl Chloroacetate with Composite Catalysts[J] Chemcial Industry and Engineering, 2011,V28(6): 6-9
2011, Vol. 28 
