Process Improvement on Synethsis of 2-Methyl-4-Trifluoro-Methyl-5-Thiazolyl Acid

化学工业与工程

Chemcial Industry and Engineering

2011, Vol. 28

Issue (4) :30-33 DOI:

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Process Improvement on Synethsis of 2-Methyl-4-Trifluoro-Methyl-5-Thiazolyl Acid

XIAO Jie, LI Wei, ZHOU Xue-Qin, LIU Dong-Zhi

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

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Abstract 2-chloro-4, 4, 4-trifluoro-acetyl ethyl acetate 3 was obtained by 4-trifluoroacetyl ethyl acetate 2 and sulfuryl chloride, 2-methyl-4-trifluoro-methyl-5-thiazolyl acid 1 in total yield of 72.3% was obtained by acidification of 2-ethyl-4-trifluoro-methyl-5-thoxycarbonylthiazole 4 which was synthesized by 3 and thioacetamide in acetonitrile with triethylamine. The structure of 1〖 was confirmed by ¹H NMR, IR and MS.

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	XIAO 　Jie
	LI 　Wei
	ZHOU Xue-Qin
	LIU Dong-Zhi

Keywords： thifluzamide 2-chloro-4, 4, 4-trifluoro-acetyl ethyl acetate 2-methyl-4-trifluoromethyl-5-thiazolyl acid

Cite this article:

XIAO Jie, LI Wei, ZHOU Xue-Qin, LIU Dong-Zhi.Process Improvement on Synethsis of 2-Methyl-4-Trifluoro-Methyl-5-Thiazolyl Acid[J] Chemcial Industry and Engineering, 2011,V28(4): 30-33

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