Abstract In this paper the new synthetic route of HCFU was based on the Curtius rearrangement reaction,in which HCFU was prepared by two steps. Firstly,the n -hexyl isocyanate was prepared from ethyl heptanoate and hydrzine hydrate by Curtius condensation reaction. And then the title compound was synthesized from 5-FU by using pyridine as solvent,in which the mixture of 0.1mol 5-Fu and 0.1mol n -hexyl isocyanate in pyridine was heated 3h at 95�� to give HCFU.
GU Feng-cai,SHI Yun-mei,WANG Yan-guang,WANG Jin-ming,NIE Jian-ming .The New Synthetic Route of HCFU[J] Chemcial Industry and Engineering, 2001,V18(5): 269-271
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2001, Vol. 18 
