Abstract Lipase-catalyzed synthesis of L-ascorbyl palmitate in non-aqueous phase was studied in this paper.The appropriate lipase and non-aqueous medium were obtained,and several factors which effect the reaction were studied.The results show that the optimum reaction conditions are:the Lipase of Novozyme 435 and tert-butyl alcohol are the optimum pair,the molar ratio of palmitic acid/Vc is 3/1,the reaction temperature is 59��,the reaction time is about 50h,the content of Novozyme 435 is 10g��L~(-1),and the purity of L-AP is up to 95% after purified.
LIU Chang-bo, GAO Rui-chang.Lipase-Catalyzed Synthesis of L-Ascorbyl Palmitate in Non-aqueous Phase[J] Chemcial Industry and Engineering, 2003,V20(6): 443-446
2003, Vol. 20 
