化学工业与工程
Home  |   |  About Journal  |  Editorial Board  |  Instruction  |  Subscriptions  |  Download  |  Publication Ethics  |  Contacts Us  |  Chinese
Chemcial Industry and Engineering 2017, Vol. 34 Issue (3) :43-49    DOI: 10.13353/j.issn.1004.9533.20151017
Current Issue | Next Issue | Archive | Adv Search << | >>
Preparation of Amino Group Modified Mesoporous Silica Nano-particles and Its Application in Hydrophobic Drug Loading and Release
Yan Jianmin, Zhang Yuqing
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

Abstract
Reference
Related Articles
Download: PDF (1802KB)   HTML ()   Export: BibTeX or EndNote (RIS)      Supporting Info
Abstract 

In order to increase drug loading capacity, the surface of MSN was functionalized with amine groups by treatment with APTS. Under the best preparation conditions, the FXD loading efficiency of MSN and MSN-NH2 was 28.1 mg/g and 39.3 mg/g. In this experiment, we studied the in vitro release properties of samples and found that the amounts of released FXD from MSN was about 67.7% for 32 h, whereas the released FXD from MSN-NH2-3 was around 59.3% for 32 h. FXD release data of MSN and MSN-NH2-3 was fitted with the Korsmeyer-Peppas model. The drug release kinetics constant of MSN-NH2-3 (k=13.41) is less than MSN(k=19.64). These results demonstrated that the FXD loading capacity of MSN-NH2 was increased by 11.2 mg/g and the FXD cumulative release capability of MSN-NH2 was decreased by 8.4%.

Service
Email this article
Add to my bookshelf
Add to citation manager
Email Alert
RSS
Articles by authors
Yan Jianmin
Zhang Yuqing
Keywordsmesoporous silica;   amino modification;   hydrophobic drug;   drug loading and release     
Received 2015-02-05;
About author:
Cite this article:   
Yan Jianmin, Zhang Yuqing.Preparation of Amino Group Modified Mesoporous Silica Nano-particles and Its Application in Hydrophobic Drug Loading and Release[J]  Chemcial Industry and Engineering, 2017,V34(3): 43-49
Copyright 2010 by Chemcial Industry and Engineering