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Chemcial Industry and Engineering 2014, Vol. 31 Issue (4) :69-74    DOI: doi: 10.13353/j.issn.1004.9533.2014.04.014
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Progress in Microbial Biosynthesis of Tacrolimus
 WAN  Tao, HUANG  Di, WEN  Jian-Ping
(School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin 300072, China)

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Abstract The present paper introduces recent progress in Tacrolimus’s physical and chemical characteristics as well as immunosuppressant activity in detail. For this purpose, the paper mainly summarizes research on fermentation production technology, the biosynthesis gene clusters and metabolic pathways. Furthermore, some successful cases of improvement about production of Tacrolimus based on metabolic engineering technology are reviewed. In future, the combination of systems biology and synthetic biology would provide rational guidance to promote the production efficiency of Tacrolimus and construct the high-yield producing strains with the improved key enzymes.
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WAN Tao
HUANG Di
WEN Jian-Ping
KeywordsTacrolimus;   immunosuppressant activity;   metabolic pathway;   metabolic engineering;   systems biology;   synthetic biology     
Received 2012-11-23;
Corresponding Authors: 闻建平,电话:(022)27892061,E-mail:jpwen@tju.edu.cn。     Email: jpwen@tju.edu.cn
About author: 万涛(1968-),男,博士研究生,正高级工程师,主要从事化工领域研究。
Cite this article:   
WAN Tao, HUANG Di, WEN Jian-Ping.Progress in Microbial Biosynthesis of Tacrolimus[J]  Chemcial Industry and Engineering, 2014,V31(4): 69-74
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