Abstract Asymmetric hydrogenation of prochiral ketones by transition metal complexes is one of the most effective methods for the synthesis of enantiomerically pure secondary alcohols, and is of great importance in the fields of pharmaceuticals, fine chemicals and advanced materials. In this paper, the chiral Ru complex containing achiral monophosphine ligand and chiral diamine ligand is synthesized and immobilized in ionic liquids. The resulting catalytic system is evaluated in the asymmetric hydrogenation of acetophenone. The effects of various reaction conditions including reaction temperature, hydrogen pressure, solvent, amount of ionic liquids, on the catalytic activity are studied in detail. The results show that the chiral catalyst can be effectively immobilized in ionic liquids, and low Ru leaching is found. The chiral catalyst can be separated simply by extraction.
DING Fei, LOU Lan-Lan, YU Kai, LI Jie, LIU Shuang-Xi.Use of Ionic Liquid in Asymmetric Hydrogenation of Acetophenone[J] Chemcial Industry and Engineering, 2013,V30(6): 11-14
2013, Vol. 30 
