��ƥ��м��4-(2-��һ�)-3-��-1,3-��-2H-��-2-ͪ�ĺϳ�

ժҪ �Ա��Ҵ�Ϊԭ��,��Friedel-Crafts��Ӧ�ϳ��ɫ��,��ſ��Ρ�ˮ��õ��-2-��һ��,�ٺ��鷴Ӧ�Ʊ�2-[2-(��)�һ�]-��-��ϩ,��ͨ��Royer��Ӧ��ƥ��м��4-(2-��һ�)-3-��-1,3-��-2H-��-2-ͪ��Ʒ��ɱ��ɫ�ס��˴Ź��ס��׷��,ȷΪĿ�Ļ��,��Ϊ31.51%��

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Abstract�� Isochroman was synthesized from phenyl ethanol by inner molecular Friedel-Crafts alkylation reaction.The intermidiate of Ropinirole 4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one was prepared from isochroman by ring opening,salt formation,hydrolysis,nitrostyrene formation and Royer reaction.The target product was confirmed by the analysis of TLC,()~(1)H-NMR,IR.The total yield is 31.51%.

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Received 2006-01-15; published 2006-01-15

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��;��;��;.��ƥ��м��4-(2-��һ�)-3-��-1,3-��-2H-��-2-ͪ�ĺϳ�[J]. ��ѧ��ҵ�빤��, 2006,23(1): 29-32

WANG Jin-gang,WANG Song-qing,ZENG Guo.Synthesis of 4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one,an Intermidiate of Ropinirole[J]. Chemcial Industry and Engineering, 2006,23(1): 29-32

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