KANG Song~1,ZHOU Zi-qing~1,GAO Rui-chang~2 (1.KYF Co.,Ltd,Beijing 100013,China;2.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)
(1.KYF Co.,Ltd,Beijing 100013,China;2.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China
Abstract��
As a new generation of progesterone product,norgestimate is widely used as an oral contraceptive,acne therapy,and hormone replacement therapy for menopausal symptoms in women.In this paper norgestimate was obtained from levonorgestrel through di-esterization,acid hydrolysis and oximization reactions. UV,IR,H-NMR,C-NMR and Mass were performed to determine the structure of intermediates and final product.Results showed the analytical sample was identical to authentic,and the chemical structure and the quality of this compound agreed with those of imported samples.
2008, Vol. 25 
