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化学工业与工程
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��ѧ��ҵ�빤�� 2008, Vol. 25 Issue (3) :229-232    DOI:
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Facile Synthesis and Chiral Separation of ��-Amino Acid Racemates
CHEN Feng,CHEN Lei(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)
(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China
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Abstract�� Optically pure ��-amino acids are important components of natural products and essential intermediates of polypeptide and ��-lactam.Traditional preparation methods involved multi-step synthesis,expensive raw materials,complicated operating procedures and low yields.In this paper,a novel approach to get ��-amino acid enantiomers was described.With aldehyde,malonic acid,ammonium acetate as raw materials,five ��-amino acid racemates were synthesized by one-pot method.These amino acids were then resolved by ligand exchange chromatorgraphy(LEC) to yield optically pure ��-amino acids.The results showed that one-pot synthesis of ��-amino acids and chiral separation by LEC was a simple and efficient method,by which the amino acid enantiomers can be produced with low cost and high yield.This method can be adopted for the preparation of ��-amino acid enantiomers with different structures used in the high throughput screening of drug candidates during the process of drug development.
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Received 2008-05-15; published 2008-05-15
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�·�;����;.��-������������ĺϳ������Է���[J].  ��ѧ��ҵ�빤��, 2008,25(3): 229-232
CHEN Feng,CHEN Lei.Facile Synthesis and Chiral Separation of ��-Amino Acid Racemates[J].  Chemcial Industry and Engineering, 2008,25(3): 229-232
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