Improved Technology of the Synthesis of 6-Chloroguanine
TONG Li,CHEN Wen-hua,LIU Qiao-yun,REN Chu-bing,ZHANG Ting(1.Department of Applied Chemistry,Changzhou Institute of Engineering Technology,Changzhou 213004,Jiangsu Province,China)
(1.Department of Applied Chemistry,Changzhou Institute of Engineering Technology,Changzhou 213004,Jiangsu Province,China
Abstract��
2-Formylamino-6-chloropurine was synthesized through the reaction of guanine with N,N-dimethylformamide and phosphorus oxychloride,then hydrolyzed under condition of pH 3��4,and through alkaline hydrolysis,neutralization to produce 6-chloroguanine.Factors influencing the reaction yield were studied,such as feeding mode and solvents for recrystallization.The optimum technical condition: phosphorus oxychloride is added dropwise to N,N-dimethylformamide at low temperature to prepare a mixing solution,then the mixing solution is dropped to the solution of 1,2-dichloroethane dissolving guanine,solvents for recrystallization is N,N-dimethylformamide.The total yield reached 78%(based on guanine) and the purity is 99%.
TONG Li,CHEN Wen-hua,LIU Qiao-yun,REN Chu-bing,ZHANG Ting.Improved Technology of the Synthesis of 6-Chloroguanine[J]. Chemcial Industry and Engineering, 2008,25(6): 523-526
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2008, Vol. 25 
