光交联PVA-SBQ/透明质酸纳米纤维的制备及性能

摘要为了增强透明质酸的耐水溶性、实现药物缓释，本研究应用静电纺技术制备改性透明质酸（GMHA）与聚乙烯醇-苯乙烯吡啶（PVA-SBQ）的复合纳米纤维膜，进一步在紫外光照射下得到光交联复合纤维膜。系统研究了不同的紫外光照时间、温度和pH值下复合纳米纤维的溶胀比以及载药释放性能，结果表明复合纳米纤维膜的溶胀比随温度升高而减小，随pH值升高而增大。光交联之后的1.0%（质量分数，下同）载药复合纳米纤维膜在10 h内的累积释放率在40%左右，释放曲线比较平缓，达到药物缓释的目的。

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	宋晓艳
	杨哲
	徐如梦
	邢金峰

关键词：载药释放聚乙烯醇-苯乙烯吡啶盐改性透明质酸静电纺丝紫外交联

Abstract： In order to enhance the water solubility of hyaluronic acid and achieve sustained drug release, this study used electrospinning technology to prepare composite nanofiber membranes of modified hyaluronic acid (GMHA) and polyvinyl alcohol-styrene pyridine (PVA-SBQ). Then the photocrosslinked PVA-SBQ/GMHA composite fibers were obtained under ultraviolet irradiation. The morphology of PVA-SBQ/GMHA nanofibers was analyzed by scanning electron microscopy. The swelling ratio and drug release performance of composite nanofibers under different ultraviolet illumination time, temperature and pH were studied systematically, which indicated that composite nanofiber membranes swelled with the increase of temperature become smaller and the degree of swelling at pH 2.2 is less than that at pH 7.2. The cumulative release rate of 1.0% drug-loaded PVA-SBQ/GMHA fiber membrane after photocrosslinking was about 40% within 10 h, and the cumulative release curve was relatively flat, which achieved the purpose of drug sustained release.

Keywords： drug release； polyvinyl alcohol-styrene pyridine(PVA-SBQ)； modified hyaluronic acid(GMHA)； electrospinning； UV crosslinking

Received 2020-02-21;

Corresponding Authors: 邢金峰,E-mail:jinfengxing@tju.edu.cn。 Email: jinfengxing@tju.edu.cn

About author: 宋晓艳(1975-),女,博士,副教授,主要从事功能高分子材料研究。

引用本文:

宋晓艳, 杨哲, 徐如梦, 邢金峰.光交联PVA-SBQ/透明质酸纳米纤维的制备及性能[J]. 化学工业与工程, 2021,38(1): 53-60

Song Xiaoyan, Yang Zhe, Xu Rumeng, Xing Jinfeng.Preparation and Characterization of Photocrosslinked PVA-SBQ/GMHA Composite Nanofibers[J]. Chemcial Industry and Engineering, 2021,38(1): 53-60

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