对甲砜基苯丝氨酸铜合成的研究

摘要以对甲砜基苯甲醛、甘氨酸、硫酸铜为原料，氨水为催化剂，研究了对甲砜基苯丝氨酸铜的合成工艺。试验结果表明，制备对甲砜基苯丝氨酸铜的最适宜工艺为：n(对甲砜基苯甲醛)∶n(甘氨酸)∶n(硫酸铜)∶n(水)为1∶ 11∶ 055 ∶170，温度50 ℃，pH值为9，反应30 h，收率为80%左右。采用薄层色谱（TLC）、液质联机（LCMS）以及红外光谱（IR）进行表征，探究并证实了该反应的机理并推测了所发生的副反应。

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	韩玉英
	宋健
	冯荣秀
	赵君彦

关键词：对甲砜基苯丝氨酸铜合成机理副反应

Abstract： The synthesis process of pmethylsulfonylphenylserine copper was studied in this paper.Methylsulfonylbenzaldehyde,glycine and copper sulfate were used as raw materials,and ammonia as catalyst.The results demonstrated the optimal conditions of the preparation process were as follows∶p-methylsulfonylbenzaldehyde∶glycine∶copper sulfate∶H2O=1∶11∶055∶170(molar ratio),reaction tempreture was 50 ℃,pH=9,reaction time was 30 hours.The yield of pmethylsulfonylphenylserine copper was approximately 80% under the optimal conditions.And they were characterized by TCL,LCMS and IR.The mechanism of the reaction was identified and the possible side reaction was speculated.

Keywords： p-methylsulfonylphenylserine copper synthesis mechanism side reaction

引用本文:

韩玉英, 宋健, 冯荣秀, 赵君彦.对甲砜基苯丝氨酸铜合成的研究[J]. 化学工业与工程, 2011,28(2): 29-34

HAN Yu-Ying, SONG Jian, FENG Rong-Xiu, ZHAO Jun-Yan.Synthesis of p-Methylsulfonylphenylserine Copper[J]. Chemcial Industry and Engineering, 2011,28(2): 29-34