YANG Xiang-yu~1,SONG Jian~1,LOU Ke-xia~1,FENG Rong-xiu~1,LIAO Hua-xue~2,DUAN Wen-jun~3(1.College of Pharmaceuticals & Biotechnology,Tianjin University,Tianjin 300072,China;2.School of Chemical Engineering,Hebei University of Technology,Tianjin 300130,China;3.Tianjin Medical University,Tianjin 300070,China)
(1.College of Pharmaceuticals & Biotechnology,Tianjin University,Tianjin 300072,China;2.School of Chemical Engineering,Hebei University of Technology,Tianjin 300130,China;3.Tianjin Medical University,Tianjin 300070,China
Abstract��
2,3,5-trichloropyridine is a valuable intermediate for producing herbicidally effective compounds.In this paper,the process for producing 2,3,5-trichloropyridine from pentachloropyridine was studied.In the process,2,3,5-trichloropyridine was obtained by reacting pentachloropyridine with zinc powder in an alkaline medium at 75��.The effect factors such as temperature,time,the amount of zinc powder etc were studied.Self-made Oldershaw column was employed to separate the resulting products and it can shorten the work-up procedures.The purity of 2,3,5-trichloropyridine was up to 97%,mp 48�桪49��.
YANG Xiang-yu~1,SONG Jian~1,LOU Ke-xia~1,FENG Rong-xiu~1,LIAO Hua-xue~2,DUAN Wen-jun~3.Synthesis of 2,3,5-Trichloropyridine[J]. Chemcial Industry and Engineering, 2004,21(2): 146-148
2004, Vol. 21 
