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Abstract�� The synthesis of piperazine and its derivatives from hydroxylamine was discussed in this paper.From N-(2-hydroxy-ethyl)-ethylenediamine,piperazine was prepared in a cyclization reaction in a yield above 95%.A catalyst containing nickel,copper,chrome,zinc and manganese using ��-Al_2O_3 as carrier was selected.The optimum conditions were determined.2-methylpiperazine and cis-2,6-dimethylpiperazine were prepared according to the similar routes.

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Received 2004-03-15; published 2004-03-15

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��,��,�׹��.�ǰ��ϳ��໯��о�[J]. ��ѧ��ҵ�빤��, 2004,21(2): 149-151

ZENG Tao,CHEN Li-gong,BAI Guo-yi.Study on the Synthesis of Piperazine and Its Derivatives from Hydroxylamine[J]. Chemcial Industry and Engineering, 2004,21(2): 149-151

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