��ӡ��ۺ��ϵ��Ʊ��Ӧ��

ժҪ ��Ϊһ��˹��ϳɼ��,��ӡ��ȡ��˳��Ľ�չ��Ĳ��˷��ӡ��Ļ��ԭ��,��ϸ��˵��塢��ӡ��ӵ�ѡ��Լ��ϵ��Ʊ��⡣ͨ��,��˹��ۼ��ǹ��ֽ��ģʽ,ָ��߸��Ե��÷�Χ;�Ƚ��3�ֲ�ͬӡ��ۺ��ϵ��Ʊ��;��ϸ��˷��ӡ��ۺ��ɫ�׷��롢��л��ϳɡ��߻��ϼ��ȸ��ľ��Ӧ�á�

	Service

	�ѱ��Ƽ��
	��ҵ��
	��ù��
	Email Alert
	RSS
	��
	��
	��
	��

�ؼ���� ӡ��ۺ�� ʶ��

Abstract�� As a technique for the synthesis of artificial receptors,molecular imprinting strategy has achieved great advances in recent years.In this article,an elucidation on the basic principles was given;the selection of monomer,cross linker and imprinting molecule,as well as the preparation of polymeric material were proposed.Based on detailed analysis,the differences concerned the characteristics of covalent and non-covalent binding forms involved in the technique were clearly demonstrated,three featured preparation methods were discussed,and the broad applications of molecularly imprinted polymers(MIPs) in the fields of chromatographic separation,sensing technique,organic synthesis,catalysis as well as environmental protections were introduced.

Keywords��

Received 2005-09-15; published 2005-09-15

��ñ��:

��,��,��.��ӡ��ۺ��ϵ��Ʊ��Ӧ��[J]. ��ѧ��ҵ�빤��, 2005,22(5): 367-370

WANG Hong, HUANG Liang, SUN Yan.Preparation and Application of Molecularly Imprinted Polymers[J]. Chemcial Industry and Engineering, 2005,22(5): 367-370

[1]	CRAMDJ.Thedesignofmolecularhosts,guestsandtheir complexes[J].Science.1988,240:760-767
[2]	WULFFG.Molecularimprintingincross linkedmaterials withtheaidofmoleculartemplates��Awaytowardsartificial antibodies[J].AngewChemIntEdEngl,1995,34:1812-1832.
[3]	WULFFG,SCHAUHOFFS.Racemicresolutionoffree sugarswithmacroporouspolymerspreparedbymolecular imprinting.Selectivitydependenceonthearrangementof functionalgroupsversusspatialrequirements[J].JOrg Chem,1991,56:395-400.
[4]	VLATAKISG,ANDERSSONLI,M LLERR,etal.Drug assayusingantibodymimicsmadebymolecularimprinting[J].Nature.1993,361:645-647
[5]	WULFFG.Enzyme likecatalysisbymolecularlyimprinted polymer[J].ChemRev,2002,102:1-27.
[6]	JENKINSAL,UYOM,MURRAYGM.Polymer based lanthanideluminescentsensorfordetectionofthehydrolysis productofthenerveagentsomaninwater[J].AnalChem,1999,71:373-378.
[7]	LEVIR,MCNIVENS,PILETSKYSA,etal.Optical detectionofchloramphenicolusingmolecularlyimprinted polymers[J].AnalChem,1997,69:2017-2021.
[8]	GLADM,REINHOLDSSONP,MOSBACHK.Molecularly imprintedcompositepolymersbasedontrimethylolpropane trimethacrylate(TRIM)particlesforefficientenantiomeric separations[J].ReactPolym,1995,25:47-54.
[9]	SCHWEITZL,ANDERSSONLI,NILSSONS.Capillary electrochromatographywithmolecularimprint based selectivityforenantiomerseparationoflocalanaesthetics[J].JChromatogrA.1997,792:401-409
[10]	BR GGEMANNO,HAUPTK,YEL,etal.New configurationsandapplicationsofmolecularlyimprinted polymers[J].JChromatogrA.2000,889:15-24
[11]	SHIH,TSAIWB,GARRISONMD,etal.Template imprintednanostructuredsurfacesforproteinrecognition[J].Nature.1999,398:593-597
[12]	LIAOJL,WANGY,HJERT NS.Anovelsupportwith artificiallycreatedrecognitionfortheselectiveremovalof proteinsandforaffinitychromatography[J].Chromatographia.1996,42:259-262
[13]	HJERT NS,LIAOJL,NAKAZATOK,etal.Gels mimickingantibodiesintheirselectiverecognitionof proteins[J].Chromatographia.1997,44:227-234
[14]	AHERNEA,ALEXANDERC,PAYNEMJ,etal.Bacteria mediatedlithographyofpolymersurface[J].JAmChem Soc.1996,118:8771-8772
[15]	DHALPK,ARNOLDFH.Metal coordinationinteractions inthetemplate mediatedsynthesisofsubstrate selective polymers:Recognitionofbis(imidazole)substratesby copper(II)iminodiacetatecontainingpolymers[J].Macromolecules.1992,25:7051-7059
[16]	VIDYASANKARS,RUM,ARNOLDFH.Molecularly imprintedligand exchangeadsorbentsforthechiral separationofunderivatizedaminoacids[J].JChromatogrA.1997,775:51-63
[17]	MAYESAG,MOSBACHK.Molecularlyimprintedpolymer beads:Suspensionpolymerizationusingaliquid perfluorocarbonasthedispersingphase[J].AnalChem,1996,68:3769-3774.
[18]	PILETSKYSA,ALCOCKS,TURNERAPF.Molecular imprinting:Attheedgeofthethirdmillennium[J].Trends Biotechnol.2001,19(1):9-12
[19]	MATSUIJ,FUJIWARAK,UGATAS,etal.Solid phase extractionwithadibutylmelamine imprintedpolymeras triazineherbicide selectivesorbent[J].JChromatogrA.2000,889:25-31
[20]	ANSELLRJ,MOSBACHK.Magneticmolecularly imprintedpolymerbeadsfordrugradioligandbindingassay[J].Analyst.1998,123:1611-1616
[21]	D SOUZASM,ALEXANDERC,CARRSW,etal.Directednucleationofcalciteatacrystal imprintedpolymer surface[J].Nature.1999,398:312-316