Abstract��
Fluorination reaction,a key process in the preparation of Dexamethasone acetate,is optimized and the optimum conditions are obtained.The ratio of raw material to HF-DMF is 5.5��1.0,the concentration of HF-DMF is 0.6 g/mL,reaction temperature is(-3 ��)��(-5 ��) and recrystallization solvent is acetone.Under the above optimum reaction conditions,the yields of crude and purified products reach 101.0% and 75.6% respectively.The purity of Dexamethasone acetate is above 98.5%.
ZHU Cui-hong~1,WEN Jian-ping~2,LU Yan-chang~1,WANG Fujun~1.Optimization of Fluorination Reaction in the Preparation of Dexamethasone Acetate[J]. Chemcial Industry and Engineering, 2005,22(6): 430-433
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2005, Vol. 22 
