新型抗病毒药物缬更昔洛韦的合成综述

摘要缬更昔洛韦是国际最新抗病毒药物,是更昔洛韦的前体药物,主要用来治疗HIV感染者(AIDS患者)因感染巨细胞病毒(CMV)所致急性视网膜炎。缬更昔洛韦的口服生物利用度比更昔洛韦高出很多,而毒性却大大降低,具有广阔的市场前景,因此综述了缬更昔洛韦的合成方法,并对各种方法进行了比较分析,总结出各自的优缺点。

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	刘巧云
	赵辉爽
	陈文华

关键词：抗病毒药物缬更昔洛韦更昔洛韦合成

Abstract： Valganciclovir is a prodrug of Ganciclovir which has been newly developed for the treatment of cytomegalovirus(CMV) retinitis in patients with Aids.The bioavailability of oral Valganciclovir is higher than Ganciclovir while the toxicity is lower,so it has a wide market prospect.In this paper,synthetic methods of Valganciclovir were analyzed and compared with each other,and the merits and defects of each method were presented.

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Received 2008-07-15; published 2008-07-15

引用本文:

刘巧云;赵辉爽;陈文华;.新型抗病毒药物缬更昔洛韦的合成综述[J]. 化学工业与工程, 2008,25(4): 344-348

LIU Qiao-yun,ZHAO Hui-shuang,CHEN Wen-hua.Review on the Synthesis of the New Antivirus Agent Valganciclovir[J]. Chemcial Industry and Engineering, 2008,25(4): 344-348