用于增强多金属氧酸盐抗肿瘤功效的靶向聚合物纳米颗粒

摘要多金属氧酸盐(POMs)是一类很有前景的医药制剂,被用于抗癌、抗菌等方面。但其水溶性差,与正常细胞有非特异性的相互作用,导致了对肝脏和肾脏的毒副作用,这些都限制了它们在临床上的实际应用。用靶向分子修饰的聚合物纳米颗粒(Nanoparticles, NPs)可以解决POMs的这些问题。在此,设计了包裹POMs的新型聚合物NPs(PLA-mPEG₁₀₀₀/TPGS₃₃₅₀-Folate),用于将POMs靶向输送到肿瘤细胞。与没有靶向功能的NPs相比,这些用叶酸(FOL)修饰的NPs在体外对MCF-7黑色素癌细胞显示出很高的抗肿瘤活性,这可能是由于通过叶酸受体介导的内吞途径增强了细胞的吸收能力。设计的这些NPs在未来治疗癌症方面具有巨大的潜力。

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	万冬
	张煜英
	王欢
	姚田子
	郭建辉
	刘钰君
	张赛晖
	潘杰

关键词：金属癌症纳米颗粒靶向叶酸

Abstract： Polyoxometalates (POMs) works as a promising agent in medicine. They are exploited for anticancer, antibacterial, and so on. But they have poor water solubility and nonspecific interactions with normal cells, resulting in toxicity side effects on liver and kidney, all of which limit their practical application for antitumor in clinic. Polymeric nanoparticles (NPs) modified with targeting molecule can solve these problems of POMs. Herein, novel polymeric NPs (PLA-mPEG₁₀₀₀/TPGS₃₃₅₀-Folate) encapsulating POMs were developed for targeted delivery of POMs to tumor cells. In comparison with NPs without targeting function, these NPs decorated with folate (FOL) illustrated high antitumor activity to MCF-7 melanoma cells in vitro, which is perhaps due to enhanced cellular take through folate receptor-mediated endocytosis pathway. As a result, it is supposed that these NPs designed in this work have enormous potential for the treatment of cancer in the future.

Keywords： polyoxometalates cancer nanoparticles target folate

Received 2023-03-14;

Fund:国家自然科学基金项目(22178270,22078246);天津市级大学生创新训练项目(202210058172)。

Corresponding Authors: 潘杰,教授,E-mail:panjie@tiangong.edu.cn。 Email: panjie@tiangong.edu.cn

About author: 万冬(1977-),女,教授;研究方向:药物缓控释高分子生物材料和抗肿瘤纳米药物。

引用本文:

万冬, 张煜英, 王欢, 姚田子, 郭建辉, 刘钰君, 张赛晖, 潘杰.用于增强多金属氧酸盐抗肿瘤功效的靶向聚合物纳米颗粒[J]. 化学工业与工程, 2023,40(5): 144-150

WAN Dong, ZHANG Yuying, WANG Huan, YAO Tianzi, GUO Jianhui, LIU Yujun, ZHANG Saihui, PAN Jie.Targeted polymeric nanoparticles for enhanced antitumor efficacy of polyoxometalates[J]. Chemcial Industry and Engineering, 2023,40(5): 144-150

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