蛋氨酸CO<sub>2</sub>酸化半间歇反应结晶动力学研究

摘要针对海因法合成蛋氨酸工艺,利用间歇动态法、以蛋氨酸钾为原料研究了CO₂酸化条件下蛋氨酸的反应结晶过程,建立结晶动力学模型。通过矩量变化法求解粒数衡算方程,利用最小二乘法对数据多元线性回归得到结晶动力学参数。结果表明:晶体生长类型为粒度无关生长,晶体生长活化能为21.01 kJ·mol^-1,成核与生长速率方程中过饱和度的指数分别为0.62和1.52,晶体聚结对结晶过程的影响不可忽略。气体表观速率、搅拌速率对晶体成核与聚结均有明显影响。高过饱和度与高搅拌转速不利于晶体平均粒径的增加。

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	陈志荣
	张福佳
	袁慎峰
	尹红

关键词：蛋氨酸反应结晶间歇动态法结晶动力学

Abstract： Aiming at the synthesis of methionine by hydantion method, using potassium methionine as raw material, the reaction crystallization process of methionine under CO₂ acidification condition was studied by batch-dynamic method, and the crystallization kinetic model was established. The population number balance equation was solved by moment method, and the crystallization kinetic parameters were obtained by fitting the data with multiple linear regression using least square method. The results show that the crystal growth is size-independent, and growth activation energy is 21.0 kJ·mol^-1. The exponents of supersaturation with respect to nucleation rate and growth rate are 0.62 and 1.52, respectively. The effect of crystal agglomeration on the crystallization process cannot be ignored. The apparent gas velocity and stirring speed have obvious effects on crystal nucleation and agglomeration. High supersaturation and high stirring speed are not conducive to the increase of average crystal size.

Keywords： methionine reaction crystallization batch-dynamic method crystallization kinetics

Received 2022-06-15;

Corresponding Authors: 尹红,教授,E-mail:yinh@zju.edu.cn。 Email: yinh@zju.edu.cn

About author: 陈志荣(1963-),男,教授,主要从事应用化学与化学工程方面的研究。

引用本文:

陈志荣, 张福佳, 袁慎峰, 尹红.蛋氨酸CO₂酸化半间歇反应结晶动力学研究[J]. 化学工业与工程, 2023,40(4): 58-66

CHEN Zhirong, ZHANG Fujia, YUAN Shenfeng, YIN Hong.Kinetics of semi-batch reaction crystallization of methionine under CO₂ acidification condition[J]. Chemcial Industry and Engineering, 2023,40(4): 58-66

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