谷胱甘肽在水-乙醇混合溶剂中的溶解度测定及关联

摘要采用称质量法测定了283.15～313.05 K下谷胱甘肽在不同配比的水-乙醇混合溶剂中的溶解度。实验结果表明，谷胱甘肽的溶解度随乙醇摩尔分数的增加而下降，随温度的升高而逐渐增大。分别用Apelblat简化方程和λh方程对溶解度数据进行关联，结果表明两种模型方程的回归效果均令人满意。利用van’t Hoff方程估算得到谷胱甘肽在水-乙醇中的溶解焓和溶解熵。两者均随乙醇摩尔分数的增加而增大。谷胱甘肽溶解度的测定及关联为其工业结晶过程设计和工艺优化提供理论依据，对工业生产具有重要的指导作用。

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	陈智
	党乐平
	卫宏远

关键词：谷胱甘肽；溶解度；混合溶剂；模型关联

Abstract： The solubilities of reduced glutathione in different proportions of water-ethanol mixtures at 283.15 K to 313.05 K were measured using the gravimetric method. It showed that the solubilities of glutathione decreased significantly with the increase of the molar fraction of ethanol. Solubility also gradually increased with increasing temperature. The experimental data were well correlated by the modified Apelblat equation and λh equation, respectively. The enthalpy and entropy of dissolution of glutathione were estimated based on regression of the solubility data by utilizing the van’t Hoff equation. They both increased with the mole fraction of ethanol increasing. The solubility data and correlations obtained in this study provide a theoretical basis for industrial crystallization process design and optimization. It has an important role in guiding industrial production.

Keywords： glutathione； solubility； mixed solvents； model correlation

Received 2013-04-08;

Fund:

教育部博士点基金资助项目 (20110032110022)；天津市自然科学基金资助项目 (11JCYBJC04600)。

Corresponding Authors: 卫宏远，电话：（022）27405754，E-mail: crystallization.wei@hotmail.com。 Email: crystallization.wei@hotmail.com

About author: 陈智(1988-)，女，硕士研究生，研究方向为药物结晶。

引用本文:

陈智, 党乐平, 卫宏远.谷胱甘肽在水-乙醇混合溶剂中的溶解度测定及关联[J]. 化学工业与工程, 2014,31(6): 29-34

CHEN Zhi, DANG Le-Ping, WEI Hong-Yuan.Measurement and Correlation of Solubilities of Glutathione in Water-Methanol Mixed Solvents[J]. Chemcial Industry and Engineering, 2014,31(6): 29-34