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化学工业与工程 2011, Vol. 28 Issue (4) :11-15    DOI:
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氨基改性的介孔分子筛对布洛芬的吸附与控制释放
 陈雷, 张翻, 邵新超, 梁俊虎, 宋丽娟
辽宁石油化工大学 辽宁省石油化工重点实验室，辽宁 抚顺 113001
Amine-Functionalized Mesoporous Materials as Carriers for Adsorption and Controlled Drug Delivery of Ibuprofen
 CHEN  Lei, ZHANG  Fan, SHAO  Xin-Chao, LIANG  Jun-Hu, SONG  Li-Juan
Liaoning Shihua University, Liaoning Key Laboratory of Petrochemical Engineering, Fushun 113001, China
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摘要 采用合成后改性将氨基嫁接进介孔MCM-41和SBA-15孔道内，对功能化的2种分子筛进行药物吸附与控制释放的研究。利用红外光谱仪(IR)、智能重量分析仪(IGA)等表征手段对吸附剂的物理结构和化学组成进行表征。对药物布洛芬(IBU)的吸附量进行比较，结果表明，氨基改性的MCM-41（MCM-41-NH2）对布洛芬的吸附性能大于氨基改性的SBA-15（SBA-15-NH2）。在pH值为2.0时，2种载体中IBU释放的相对最慢，S-NH2-IBU比M-NH2-IBU释放的缓慢；在pH值为4.0时，S-NH2-IBU则比M-NH2-释放的要快；而在pH值为7.4时，2种载体中IBU释放速率相对比较快，S-NH2-IBU比M-NH2-IBU释放的要快。缓释速率的不同可能是源于2种分子筛不同的形态和孔道结构。
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陈雷
张翻
邵新超
梁俊虎
宋丽娟
关键词： MCM-41-NH2   SBA-15-NH2   布洛芬   吸附   缓释     
Abstract： Mesoporous materials were modified with amine groups after synthesis, the functionalized MCM-41 and SBA-15 were investigated as matrix for adsorption and controlled drug delivery. The structure, composition and framework of the matrix were characterized by infrared spectrometer (IR) and intelligent gravitation analyzer (IGA). MCM-41-NH2 showed higher loading capacity of IBU than SBA-15-NH2. Releasing experiments showed, IBU released more slowly from two medium at pH=2.0, and released more slowly from S-NH2-IBU than that from M-NH2-IBU, while faster from S-NH2-IBU than that from M-NH2-IBU at pH=4.0. But IBU released relatively faster at pH=7.4, IBU released faster form S-NH2-IBU than that from M-NH2-IBU. Different releasing rates may result from the different morphology and pore structure of the carrier particles.
Keywords： MCM41NH2   SBA15NH2   ibuprofen   adsorption   drug delivery     
Fund:

国家自然基金资助项目（20976007）
引用本文:   
陈雷, 张翻, 邵新超, 梁俊虎, 宋丽娟.氨基改性的介孔分子筛对布洛芬的吸附与控制释放[J].  化学工业与工程, 2011,28(4): 11-15
CHEN Lei, ZHANG Fan, SHAO Xin-Chao, LIANG Jun-Hu, SONG Li-Juan.Amine-Functionalized Mesoporous Materials as Carriers for Adsorption and Controlled Drug Delivery of Ibuprofen[J].  Chemcial Industry and Engineering, 2011,28(4): 11-15
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