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Chemcial Industry and Engineering 2001, Vol. 18 Issue (5) :285-289    DOI:
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Synthesis of Esters of Taxotere Side Chain
LI Chun-bao,WANG Chao,LI Nan,ZHAO Chun-chang,ZHANG Wen-qin,ZHAO Li-ping (School of Science,Tianjin University,Tianjin 300072,China)
(School of Science,Tianjin University,Tianjin 300072,China

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Abstract Eight Taxotere side chain esters (2-hydroxy-3-phenyl-3-(t\|butyloxycarbonyloxyamino)proponates)(D) were synthesized by opening of the ring of 3-ethoxyethoxy-4-phenyl-2-azetidinone (B)in the presence of alcohol and NaHMDS followed by deprotection with AcOH.These are all new compounds.Their structures were confirmed by IR,\+1HNMR and elementary analysis.)
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Received 2001-09-15; published 2001-09-15
Cite this article:   
LI Chun-bao,WANG Chao,LI Nan,ZHAO Chun-chang,ZHANG Wen-qin,ZHAO Li-ping .Synthesis of Esters of Taxotere Side Chain[J]  Chemcial Industry and Engineering, 2001,V18(5): 285-289
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