Abstract Propargyl alcohol was protected by dihydrophran with the catalysis of PPTS,and then reacted with Ethyl Mag bromide to prepare its corresponding Grignard reagent.Methyl 4-hydroxy-2-butynoate THP ether was obtained after reacting with methylchloroformate.Deprotection proceeded with the catalysis of PPTS,followed by mesylization and bromide displacement with sodium bromide to give methyl 4-bromo-2-butynoate.The overall yield was 53%.
2003, Vol. 20 
