Advance in Preparation of Biodegradable Nanoparticles

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Abstract As a new drug delivery and controlled release device,biodegradable polymeric nanoparticles appear to be very promising and have been widely studied. Nanoparticles have more advantages over the microparticles,such as lowering toxicity,shielding odor and controlling release of drug effectively.Due to their subcellular size, nanoparticles can be absorbed by the cells through the tissue matrix and penetrate into the arterial wall without causing trauma,and even be able to cross the blood-brain barrier(BBB). This review emphasizes to introduce the manufacturing techniques of biodegradable nanoparticles and their influence factors.

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Received 2004-07-15; published 2004-07-15

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ZHANG Shuang-nan, XU Xiao-qiu, LI Jing-qing, CHANG Jin .Advance in Preparation of Biodegradable Nanoparticles[J] Chemcial Industry and Engineering, 2004,V21(4): 259-262

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