Abstract 3-Mercaptopropionic acid has been synthesized from 3-chloropropionic acid and the factors which may affect the reaction have been investigated.It is shown that the pH of the reaction medium,the substitute reaction time,the time of acid cleavage and the amount of Zn affect the reaction obviously.When the pH of the reaction medium is 7,the substitute reaction time is 8 h,the time of acid cleavage is 2 h and the amount of Zn is 0.77 mol/mol(3-chloropropionic acid),the yield of 3-mercaptopropionic acid is 78% and the minimum purity is 99%(GC).With Fe as reducting agent the product yield is 80%.
LIU Fu-de,WANG Mi,GAO Su-hua,HAN Bao-cheng.Synthesis of 3-Mercaptopropionic Acid from 3-Chloropropionic Acid[J] Chemcial Industry and Engineering, 2006,V23(2): 130-132
2006, Vol. 23 
