Lipase-Catalyzed Enantioselective Esterification of (dl)-Menthol in Ionic Liquids and Organic Solvents

化学工业与工程

Chemcial Industry and Engineering

2006, Vol. 23

Issue (6) :480-485 DOI:

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Lipase-Catalyzed Enantioselective Esterification of (dl)-Menthol in Ionic Liquids and Organic Solvents

YUAN Yi,BAI Shu,JIANG Xiao-yan(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)

(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

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Abstract Enantioselective esterification of(dl)-menthol was studied in ionic liquids and organic solvents of different hydrophobicities.Because the enzyme showed comparable conversion yield and enantioselectivity in and hexane,more work focused on these two reaction media.Comparison of the activity,stability and enantioselectivity was carried out by examining the effects of temperature,incubation time and enzyme recycling.It was found that temperature control was more crucial in the ionic liquid than in hexane to reach high conversion and enantioselectivity.The ionic liquid system showed an advantage of using less acid anhydride to achieve higher(dl)-menthol conversion yield and better enantioselectivity.Moreover,during an incubation of 4 d to 60 d in the ionic liquid,CRL activity was 2.5 times higher than its initial value,while that in hexane decreased to 60% in 2 d.In addition,the enzyme showed potentiality of recycled use in the ionic liquid.These advantages of the ionic liquid suggest that it would be used as a green alternative of organic solvents for the enantioselective esterification of(dl)-menthol.

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Received 2006-11-15; published 2006-11-15

Cite this article:

YUAN Yi,BAI Shu,JIANG Xiao-yan.Lipase-Catalyzed Enantioselective Esterification of (dl)-Menthol in Ionic Liquids and Organic Solvents[J] Chemcial Industry and Engineering, 2006,V23(6): 480-485

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