Preparation of Paclitaxel-Loaded Polymeric Micelles by Dialysis Method

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Abstract Poly(ethylene glycol)(PEG)-conjugated linoleic acid(CLA)(PEG-CLA) polymeric conjugate was synthesized using 4-dimethylaminopyridine(DMAP) and dicyclohexycarbodiimide(DCC) as catalyst and coupling agent,respectively.PEG-CLA polymer was employed as carrier,the paclitaxel-loaded micelles were prepared by dialysis method.The size and size distribution,the structure and the surface chemistry of micelles were characterized by dynamic light scattering(DLS),transmission electron microscopy(TEM) and X-ray photoelectron spectroscopy(XPS),respectively.The in vitro release profiles of paclitaxel from polymeric micelles were investigated in pH7.4 phosphate buffer solution(PBS) and 1 mol/L sodium salicylate medium.The results show that the paclitaxel-loaded micelles have spherical shapes,particle size of 100 nm and narrow size distribution.XPS indicates that the drug is not absorbed on the micelles surface and sodium salicylate medium can accelerate the release rate of paclitaxel from polymeric micelles.

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Received 2007-01-15; published 2007-01-15

Cite this article:

WANG Cai-xia,FENG Xia,XU Fang,LIN Bao-rui.Preparation of Paclitaxel-Loaded Polymeric Micelles by Dialysis Method[J] Chemcial Industry and Engineering, 2007,V24(1): 24-27

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