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Chemcial Industry and Engineering 2008, Vol. 25 Issue (3) :251-258    DOI:
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Enantioselective Synthesis of Fluoxetine Hydrochloride
CAO He,LI Ai-jun,ZHOU Xue-qin,LIU Dong-zhi(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)
(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

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Abstract Fluoxetine hydrochloride is a potent and highly selective inhibitor of neutral serotonin-reuptake and is one of the most important drugs for the treatment of psychiatric disorders and metabolic problems.Due to its market value and the different pharmacological activities displayed by analogues of fluoxetine, several synthetic methods,including the enantioselective synthesis of both enantiomers,have been reported.Progress in enantioselective synthetic methods of fluoxetine hydrochloride were reviewed in this paper.
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Received 2008-05-15; published 2008-05-15
Cite this article:   
CAO He,LI Ai-jun,ZHOU Xue-qin,LIU Dong-zhi.Enantioselective Synthesis of Fluoxetine Hydrochloride[J]  Chemcial Industry and Engineering, 2008,V25(3): 251-258
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