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Chemcial Industry and Engineering 2017, Vol. 34 Issue (3) :30-36    DOI: 10.13353/j.issn.1004.9533.20151100
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The Solubility Measurement and Correlation of Trans-4-Hydroxycyclohexyl Desloratadine
Xue Tong, Zhang Richeng, Yan Xilong
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

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Abstract 

The solubility of trans-4-hydroxycyclohexyl desloratadine in water and the binary mixtures of 10% water+methanol, 20% water+methanol, 10% water+ethanol and 20% water+ethanol at the temperature range from 293.15 to 323.15 K at 101.3 kPa were measured using the HPLC (High Performance Liquid Chromatography) method. The obtained results were correlated with the modified Apelblat equation and the λh equation. Its enthalpy and entropy in the selected solvents were calculated based on the van't Hoff equation. It was found that the solubility of trans-4-hydroxycyclohexyl desloratadine increased with the increase of temperature, and decrease of polarity of solution. The dissolution processes in the above solvents were demonstrated to be an endothermic and entropy-driven over the investigated temperature range.

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Xue Tong
Zhang Richeng
Yan Xilong
Keywordstrans-4-hydroxycyclohexyl desloratadine;   solubility;   Apelblat equation;   λh equation;   van't Hoff equation     
Received 2015-06-05;
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Xue Tong, Zhang Richeng, Yan Xilong.The Solubility Measurement and Correlation of Trans-4-Hydroxycyclohexyl Desloratadine[J]  Chemcial Industry and Engineering, 2017,V34(3): 30-36
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