化学工业与工程
Home  |   |  About Journal  |  Editorial Board  |  Instruction  |  Subscriptions  |  Download  |  Publication Ethics  |  Contacts Us  |  Chinese
Chemcial Industry and Engineering 2016, Vol. 33 Issue (4) :28-32    DOI: 10.13353/j.issn.1004.9533.20141096
Current Issue | Next Issue | Archive | Adv Search << | >>
Preparation and Characterization of Atorvastatin Calcium Form I & Ⅱ
Wang Yuewei1, Zhang Tianwei2, Liu Quan2, Zhang Shixin1, Gong Junbo2
1. Tianjin Hengbida Chemical Synthesis Co. Ltd., Tianjin 301708, China;
2. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

Abstract
Reference
Related Articles
Download: PDF (1587KB)   HTML ()   Export: BibTeX or EndNote (RIS)      Supporting Info
Abstract 

In this paper, atorvastatin calcium form I was prepared from atorvastatin lactone. Form Ⅱ was obtained through the slurring experiment of form I. Forms I and Ⅱ were further characterized by scanning electron microscopy, powder X-ray diffractometry, KF water content analysis, thermal analysis and isothermal moisture absorption analysis. The results indicate that forms I and Ⅱ are both trihydrate; Form I contains two channel water and one isolated site water in its crystal lattice; Form Ⅱ is channel hydrate.

Service
Email this article
Add to my bookshelf
Add to citation manager
Email Alert
RSS
Articles by authors
Wang Yuewei
Zhang Tianwei
Liu Quan
Zhang Shixin
Gong Junbo
Keywordsatorvastatin calcium;   hydrate;   adsorption;   desorption     
Received 2014-04-29;
About author:
Cite this article:   
Wang Yuewei, Zhang Tianwei, Liu Quan, Zhang Shixin, Gong Junbo.Preparation and Characterization of Atorvastatin Calcium Form I & Ⅱ[J]  Chemcial Industry and Engineering, 2016,V33(4): 28-32
Copyright 2010 by Chemcial Industry and Engineering