Amine-Functionalized Mesoporous Materials as Carriers for Adsorption and Controlled Drug Delivery of Ibuprofen

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Abstract Mesoporous materials were modified with amine groups after synthesis, the functionalized MCM-41 and SBA-15 were investigated as matrix for adsorption and controlled drug delivery. The structure, composition and framework of the matrix were characterized by infrared spectrometer (IR) and intelligent gravitation analyzer (IGA). MCM-41-NH₂ showed higher loading capacity of IBU than SBA-15-NH₂. Releasing experiments showed, IBU released more slowly from two medium at pH=2.0, and released more slowly from S-NH₂-IBU than that from M-NH₂-IBU, while faster from S-NH₂-IBU than that from M-NH₂-IBU at pH=4.0. But IBU released relatively faster at pH=7.4, IBU released faster form S-NH₂-IBU than that from M-NH₂-IBU. Different releasing rates may result from the different morphology and pore structure of the carrier particles.

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	CHEN Lei
	ZHANG Fan
	SHAO Xin-Chao
	LIANG Jun-Hu
	SONG Li-Juan

Keywords： MCM41NH2 SBA15NH2 ibuprofen adsorption drug delivery

Fund:

国家自然基金资助项目（20976007）

Cite this article:

CHEN Lei, ZHANG Fan, SHAO Xin-Chao, LIANG Jun-Hu, SONG Li-Juan.Amine-Functionalized Mesoporous Materials as Carriers for Adsorption and Controlled Drug Delivery of Ibuprofen[J] Chemcial Industry and Engineering, 2011,V28(4): 11-15

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