紫杉醇和三尖杉磷碱色谱过程的模型研究(Ⅰ)

摘要采用考虑了轴向扩散、液膜传质阻力和固定相孔内扩散传质阻力的普遍化速率模型研究紫杉醇和三尖杉磷碱的色谱过程 ;利用有限元和正交配置法对模型方程进行了数值求解。与紫杉醇和三尖杉磷碱的正相色谱数据进行比较的结果显示 :模型能够与试验数据吻合得较好 ,轴向扩散不是影响紫杉醇和三尖杉磷碱色谱分离的主要因素 ,可以使两者的色谱分离在较高流速下操作。

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	杨军
	刘斌
	元英进

关键词：液相色谱普遍化速率模型有限元和正交配置紫杉醇三尖杉磷碱

Abstract： The general rate model considering axial dispersion,film mass transfer and effective diffusion in particle was adopted to study the chromatography process of taxol and cephalmonnine.The finite element and orthogonal collocation method was used to transfer these equations to ordinary differential equations and to solve them.The comparison between theory and experiment showed that the model could be agreement with the experimental data very well.In addition,the experiment also showed that axial dispersion is not the main factor affecting the chromatography separation of taxol and cephalmonnine.This made the operation could be done under high linear velocity of flow phase.

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Received 2000-05-15; published 2000-05-15

引用本文:

杨军,刘斌,元英进.紫杉醇和三尖杉磷碱色谱过程的模型研究(Ⅰ)[J]. 化学工业与工程, 2000,17(3): 125-130

YANG Jun,LIU Bin,YUAN Ying jin .Study on Model Used in the Chromatography Process of Taxol and Cephalmonnine(Ⅰ)[J]. Chemcial Industry and Engineering, 2000,17(3): 125-130