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Abstract�� This review summarized the main asymmetric synthetic methods,which included Friedel-Craft reaction,rearrangement reaction,��-methylation reaction,Sharpless reaction,Grignard Cross-coupling reaction,hydrogenation reaction,carbonylation reaction,enzyme-catalyzed reaction,especially for naproxen.��

Keywords��

Received 2004-01-15; published 2004-01-15

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��С��,��,��.��-��᲻�Գƺϳ��о��չ[J]. ��ѧ��ҵ�빤��, 2004,21(1): 53-56

CHEN Xiao-lin,ZHANG Ming-jie,FAN Xiao-huan��.Advances in the Asymmetric Synthesis of Optically Active 2-Arylpropanoic Acids[J]. Chemcial Industry and Engineering, 2004,21(1): 53-56

[1]	�š��.��г�͸��[J].�й��ҩ��Ϣ,2002,18(8):32.
[2]	��Ԫ��,��ҫ��.��Գƴ߻��Ӧ��չ[M].��:��ѧ��,2000.
[3]	��־��,��ع��,��ݿ�.(S)-2-��᲻�Գƺϳ��о��չ[J].�л��ѧ,2002,22(1):22.
[4]	PICCOLOO,DELGUG,VALOTIE.SterrespecificFriedel-Craftsalkylationofaromaticcompounds:synthesisofopticallyactive2-and3-arylalkanoicesters[J].JOrgChem,1991,56:183.
[5]	AXELBRAIT,HECTORGONZALEZ,PATRICIAIANDY.Alkylationof2-methoxynaphthalenewithpropyleneoxideusingtitaniummolecularsieves[J].AppliedCatalysisA:General,2000,194-195:265.
[6]	TSUCHIHASHI,ORIA,HONDAYA.Generalsyntheticmethodofchiral2-arylalkanoicestersviathermal1,2-rearrangement[J].BullChemSocJpn,1987,60:1027.
[7]	CASTADLDIG,CAVICCHIOLIS,GIORDANOC,etal.Tartaricacid,anefficientchiralauxiliary:newasymmetricsynthesisof2-alkyl-2-aryladticacids[J].JOrgChem,1987,52:3018.
[8]	TSUCHIHASHIG.Synthesisofopticallyactive2-arylalkaniocacidsbytheuseof1,2-rearrangementofthearylgroup[J].TetrahedronLett,1982,23:5427.
[9]	��ϣ,��֦,�Ժ��.��ʹҩ��Գƺϳ�[J].ҩѧѧ��,1999,34(4):290.
[10]	��,��Ʊ�,��ΰ,��.S-��Ĳ��Գƺϳ�[J].��Ṥ��ѧѧ��,2000,19(5):500.
[11]	FUJIK,NODEM,TANAKAF,etal.Binaphtholasachiralauxiliaryasymmetricalkylationofarylaceticacid[J].TetrahedronLett.1989,30:2825-
[12]	HIROOYUKIISSHIBASHI,MOMOEMAEKI,JUNKOYAGI,etal.Amodificationoftheasymmetricdihyoxylationapproachtothesynthesisof(S)-2-arylpropanoicacids[J].Tetrahedron.1999,55:6075-
[13]	HAMONPG,COGHLANDDR,MASSY-WESTROPPRA,etal.Asymmetricsynthesisofibuprofenandketoprofen[J].Tetrahedron:Asymmetry,1994,1:299.
[14]	HAYASHIT,KEWAMURAN.Asymmetrichydrogenationoftrisubstitutedacrylicacidscatalyzedbyachiral(aminoalkyl)ferrocenylphosphine-Rhodiumacid[J].JAmChemSoc,1987,109:7876.
[15]	��.��ò��Գƽ��ż��Ӧ�ϳ�(S)-(+)-��[J].��մ�ѧѧ��(��Ȼ��ѧ��),2002,26(2):77.
[16]	PAICHENGCHAO,LIYUEMING,ZHOUZHONGYUAN,etal.Synthesisofnewchiraldiphosphineligand(BisbenzodioxanPhos)anditsapplicationinasymmetriccatalytichydrogenation[J].TetrahedronLett.2002,43:2789-
[17]	ZHOUHY,CHENGJ,L��SJ,etal.CatalyticCarbonylationof��-(6-methoxyl-2-naphthyl)ethanoltomethylesterofnaproxenusingPdCl2-CuCl2-PPh3-acidcatalystsystem[J].JOrganometChem,1998,39:239.
[18]	EUNDUCKPAPK,KYUNGHEELEE,JAESUNGLEE.Easilyseparablemolecularcatalysis[J].molecularcatalysis:catalysisToday,2000,63:147.
[19]	��,�Ĵ��.PVP-PdCl2CuCl2 PPh3��ϵ�߻��-(6-��2-��)�Ҵ��ʻ��Ӧ�о�[J].��Ӵ߻�,2001,15(2):129.
[20]	ROSSIRF,HEEFNERDL.Enantioselectiveproductionofchiralcarboxylicacids[P].US:5273895,1993-12-28.
[21]	GARICAM,DELCAMPOC.Chemoenzymaticsynthesisofpureanantimericarylpropanicacids[J].Tetrahedron.1993,49(37):8433-
[22]	THANIKAVELUMANIMARAN,PATRICKSTAHLYG.Opticalpurificationofprofendrugs[J].Tetrahedron:Asymmetry.1993,4(8):1949-
[23]	MARINACRETICH,MARCELLACHIARI,GIACOMOCARREA.Stereselectivesynthesisof(S)-(+)-naproxencatalyzedbycarboxylesteraseinamulticompartmentelectrolyzer[J].JBiochemBiophysMethods,2001,48:247.