乙酰-D-蛋氨酸消旋工艺的研究

摘要在酶法拆分蛋氨酸的工艺中,经离子交换分离L-蛋氨酸后余下的N-乙酰基-D(L)-蛋氨酸溶液进行消旋反应,可将一部分N-乙酰基-D-蛋氨酸转变成L型乙酰基蛋氨酸后,可重新作为N-乙酰基D、L-蛋氨酸拆分底物使用。本文针对目前工厂实际生产中消旋产量和收率不太好的现状,利用正交试验法对影响消旋的各个因素作了分析,得出了较适宜的工艺条件,提高了产品的质量和收率。

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	张清玉
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	张新法

关键词： N-乙酰-D(L)-蛋氨酸 D-蛋氨酸 L-蛋氨酸消旋

Abstract： In the process of resoluting methionine with enzyme,L-Met is isolated by ion-exchanger,the mainly remnant will be N-acetyl-D(L)-Met.After the racemic of the remnants,some N-acetyl-D-Met will be transformed into N-acetyl-L-Met,then they can be reused as the resolute substrate.In this paper,considering the not high yield and the poor quality of the products in the factories,we designed orthogonal experiments to analysis the factors which affect the racemic process.The appropriate conditions were got,the quality and the yield were improved as well.

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Received 2004-03-15; published 2004-03-15

引用本文:

张清玉,谭欣,赵林,宋正孝,贾晓波,张新法.乙酰-D-蛋氨酸消旋工艺的研究[J]. 化学工业与工程, 2004,21(2): 91-95

ZHANG Qing-yu~1,TAN Xin~1,ZHAO Lin~1,SONG Zheng-xiao~1,JIA Xiao-bo~2,ZHANG Xin-fa~2.Study on the Racemic of N-Acetyl-D-Methionine[J]. Chemcial Industry and Engineering, 2004,21(2): 91-95