Improved Synthesis of 2-Allyl-4-Hydroxy-2-Cyclopentenone
SHAO Huai-qi~(1,2),FENG Ya-qing~1,HONG Hao~2,FAN Jin-lin~2,TIAN Chang-hai~2(1.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;2.Asymchem Laboratories(Tianjin) Co.,Ltd.,Tianjin 300457,China)
(1,2),FENG Ya-qing~1,HONG Hao~2,FAN Jin-lin~2,TIAN Chang-hai~2(1.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;2.Asymchem Laboratories(Tianjin) Co.,Ltd.,Tianjin 300457,China
Abstract��
2-allyl-4-hydroxy-2-cyclopentenone,a key synthetic intermediate for the synthesis of prostaglandins of 4-thia-PGI_1,is of important biological activity.2-allyl-4-hydroxy-2-cyclopentenone was synthesized from furfural by an improved method through Grignard reaction and rearrangement reaction.The effects of the acid catalyst,solvent,acid concentration and reactive temperature on the rearrangement were investigated.The results showed that polyphosphoric acid has better catalytic aceivity,the yield of the rearrangement is 79% and purity is 99.2% at 100 �� when molar rate of polyphosphoric acid to raw material is 0.2.The total yield is 64%.
2007, Vol. 24 
