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Abstract�� Based on the obtained pseudo-ternary phase diagrams,the effects of surfactants,cosurfactants and oils on the microemulsion were studied and the formulations were optimized.From the formulation the stable metformin loaded water-in-oil microemulsion could be prepared using teaoil/Tween 80-Span85/PEG400/water system.The mean diameter of the microemulsions determined by the Photon Correlation Spectroscopy was 46.3 nm with Gauss distribution.The content of metformin loaded in microemulsions was analyzed by UV method.The average recovery by UV method was 99.56% with standard deviation of 1.23%.The metformin microemulsion prepared was pharmaceutically acceptable and the method to determine the concentration of metformin was acute and reliable.

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Received 2007-11-15; published 2007-11-15

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��־��;��;��ٸ�;��;��;.��˫��΢��Ʊ��京��[J]. ��ѧ��ҵ�빤��, 2007,24(6): 505-509

XU Zhi-bin~1,LIU Ming-yan~1,JIANG Rong-gao~2,WANG Chun-long~2,LIU Zheng-jun~1.Preparation and Content Analysis of Metformin Microemulsion[J]. Chemcial Industry and Engineering, 2007,24(6): 505-509

[1]	CILEK A,CELEBI N,TIRNAKSIZ F,et al.A lecithin-based microemulsion of rh-insulin with aprotinin for oraladministration:Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats[J].Int J Pharm.2005,298(1):176-186
[2]	LAWRENCE M J,REES G D.Microemulsion-based mediaas novel drug delivery systems[J].Adv Drug Deliv Rev.2000,45(1):89-121
[3]	PODLOGAR F,GASPERLIN M,TOMSIC M,et al.Structural characterisation of water-Tween40/Imwitor308-isopropyl myristate microemulsions using differentexperimental methods[J].Int J Pharm.2004,276(1/2):115-128
[4]	KREILGARRD M,PEDERSEN E J,JAROSZEWSKI J W.NMR characterisation and transdermal drug deliverypotential of microemulsion systems[J].J Control Release.2000,69(3):421-433
[5]	½��,��ȫ.��ͼ��о�ҩ��΢��γ��[J].ҩѧѧ��,2001,36(1):58-62.
[6]	½��.ҩ��¼��¼��[M].��:��,1998.
[7]	LYONS K C,CHARMAN W N,MILLER M,et al.Factors limiting the oral bioavailability of N-acetylglucos-aminyl-N-acetyl-muramyl dipeptide(GMDP)andenhancement of absorption in rats by delivery in a water-in-oil microemulsion[J].Int J Pharm.2000,199(1):17-26
[8]	WARISNOICHAROEN W,LANSLEY A B,LAWRENCEM.Nonionic oil-in-water microemulsions:The effect of oiltype on phase behavior[J].Int J Pharm.2000,198(1):7-16
[9]	SCHECHTER R S.Microemulsion and Related Systems[M].New York:Marcel Dekker,1998.
[10]	��,��,��,��.��ͪ΢��Ʊ��[J].�й��ҩ��־,2003,28(11):1 081-1 085.
[11]	��ѩ��,��ѩ��,��,��.��A΢��ڷ�Һ��Ʊ��ȶ��Ե��о�[J].�й��ִ�Ӧ��ҩѧ,2004,21(1):40-43.
[12]	�Ž��,��ѫ,��ԭ,��.��΢��Ƽ��[J].�й�ҽԺҩѧ��־,2003,23(1):9-14.