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ժҪ �ԿǾ��(Cs)��(Gel)Ϊԭ��,��Һ��۷��Ʊ��˶�ҩ��л��õ�΢��Ϊģ��ҩ��,�ֱ�ͨ��ͪ��ҩ/��¸��﷨��ҩ/��/�䶳��﷨,�Ƶò�ͬ��ҩ��΢��,��ʺ��ͷ��Ϊ��о��,��ȩ(GD)��Ǿ��(Cs)��Ϊ0.40~0.53,��ҩ��20%~30%(��)֮��ʱ,�Ǿ��-��ҩ΢��15 h��ͷ�75%��,��ʿ��Դﵽ40%~50%,Ϊ��Ǿ��-��΢��Ӧ��ҽѧ��ṩ��

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Abstract�� A chitosan-gelatin drug-loaded microsphere with controlled release characteristic was prepared from chitosan and gelatin by emulsion coagulation method.Microspheres loaded with different quantity of drug were prepared via acetone marination-room temperature dried method and HCl marination-NaOH regeneration-freeze-dried method using isoquinoline as model drug,and then drug encapsulation and release behavior were studied.When the ratio of glutaraldehyde to chitosan was between 0.40 and 0.53 and drug loaded quantity was 20%��30%(mass ratio),nearly 75% drug was released during the first 15 h,and the ratio of drug encapsulation kept 40%��50%.The results provided foundational data for the application of chitosan-gelatin drug-loaded microsphere in biomedical field.

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Received 2008-05-15; published 2008-05-15

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Ҧ��;��;��;.�Ǿ��-��ҩ΢��Ʊ��ͷ��[J]. ��ѧ��ҵ�빤��, 2008,25(3): 215-219

YAO Fang-lian,YU Xiao,ZHOU Yu-tao.Preparation of Chitosan-Gelatin Drug Loading Microshpere and Its Release Characteristics[J]. Chemcial Industry and Engineering, 2008,25(3): 215-219

[1]	VASIR J K,TAMBWEKAR K,GARG S.Bioadhesivemicrospheres as a controlled drug delivery system[J].International Journal of Pharmaceutics.2003,255(1):13-32
[2]	��.��΢��Ƽ��о��չ[J].ҽҩ��,2004,23(11):843-844.
[3]	�Ű��,Ҧ��.��޽�տǾ��/��΢��Ʊ��ͷ��о�[J].�߷��ͨ��,2006,4:60-64.
[4]	SZCZUBIALKA K,ZOMERSKA K,KAREWICZ A,et al.Novel drug carrier-chitosan gel microspheres with covalentlyattached nicotinic acid[J].Journal of Controlled Release.2006,116(2):13-15
[5]	MLADENOVSKA K,KUMBARADZI E F,DODOV G M,etal.Biodegradation and drug release studies of BSA loadedgelatin microspheres[J].International Journal ofPharmaceutics.2002,242(1):247-249
[6]	DUMITRIU S,CHORNET E.Inclusion and release ofproteins from polysaccharide-based polyion complexes[J].Advanced Drug Delivery Reviews.1998,31(3):223-246
[7]	MORNI N M,MOHAMED N S,AROF A K.Silver nitratedoped chitosan acetate films and electrochemical cellperformance[J].Materials Science and Engineering B.1997,45(1):140-146
[8]	��ε,��,�ż�.�Ǿ��΢��ҩ��Ƶ��о�[J].��ҽѧԺѧ��,2000,23(1):7.
[9]	YAO K D,XU M X,YIN Y J,et al.pH-sensitive chitosan/gelatin hybrid polymer network microspheres for delivery ofcimetidine[J].Polymer International.1996,39(4):333-337