固液溶解平衡研究进展

摘要

介绍了固液溶解平衡的研究方法，分析了影响溶解平衡的因素，对常用的溶解平衡测定方法如平衡法和动态法做了介绍，并分析比较了这些方法与其他分析技术相结合的应用情况。为新药物溶解度的测定和结晶分离中物质溶解度的测定提供了一些参考。

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	许奎
	朱静
	胡雪
	王睿哲
	李红果
	李天祥

关键词：溶解平衡；饱和溶液；介稳态；溶解度测定

Abstract：

The paper summarizes the research methods of solid solution equilibrium, and analyzes the factors which influence the dissolution balance. The commonly used methods such as balance method and dynamic method are introduced, and the application of these methods with other analytical techniques are compared. It provides some references for the determination of solubility of new drugs and the determination of solubility of substances in crystallization separation.

Keywords： dissolution equilibrium； saturated solution； metastable； solubility determination

Received 2018-03-10;

Fund:

贵州大学研究生创新基金资助项目（研理工2017009号）。

Corresponding Authors: 李天祥,E-mail:txli@gzu.edu.cn。 Email: txli@gzu.edu.cn

About author: 许奎(1990-),男,硕士研究生,研究方向:化学工程。

引用本文:

许奎, 朱静, 胡雪, 王睿哲, 李红果, 李天祥.固液溶解平衡研究进展[J]. 化学工业与工程, 2018,35(3): 22-28

Xu Kui, Zhu Jing, Hu xue, Wang Ruizhe, Li Hongguo, Li Tianxiang.Research and Development of Liquid-Solid Solution Equilibrium[J]. Chemcial Industry and Engineering, 2018,35(3): 22-28

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