阿奇霉素二水合物溶析结晶工艺优化

摘要针对阿奇霉素二水合物的溶析结晶工艺,考察了结晶的初始浓度、溶析剂流加速率以及搅拌强度对结晶产品的粒度分布的影响规律,确定了优化的工艺参数为结晶温度40 ℃,初始浓度0.32 g/g,搅拌速率为200 r/min,溶析剂滴加速率为200 μL/min。在此条件下可获得粒度分布约为300 μm到800 μm且主粒度约为580 μm的产品,克服目前结晶产品存在的聚结、粒度分布不均一等问题。

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关键词：阿奇霉素; 溶析结晶; 粒度分布; 聚结

Abstract： In this paper, the influence of initial concentration, pumping rate of anti-solvent and agitation intensity on the crystal size distribution (CSD) of products was considered and then an optimized crystallization technology was proposed. The optimized products were obtained at 40 ℃ with 0.32 g/g initial concentration, 200 r/min agitation rate and 200 μL/min feeding rate. The CSD of products is from 300 μm to 800 μm and the mean crystal size is 580 μm.

Keywords： Azithromycin; dilution crystallization; crystal size distribution agg;lomeration

Received 2013-04-11;

Corresponding Authors: 龚俊波,E-mail:junbo_gong@tju.edu.cn。 Email: junbo_gong@tju.edu.cn

About author: 马博爱(1987-),男,硕士研究生,现从事药物结晶方面的研究。

引用本文:

马博爱, 龚俊波.阿奇霉素二水合物溶析结晶工艺优化[J]. 化学工业与工程, 2015,32(1): 37-40

Ma Boai, Gong Junbo.Optimization of Crystallization Process of Azithromycin Dihydrate[J]. Chemcial Industry and Engineering, 2015,32(1): 37-40

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