环丙沙星在溶液中固液表面能的测定

摘要采用激光法测定了环丙沙星在纯水和水乙醇溶液 (水体积分数 2 3% )中的溶解度 ,介稳区和不同条件下的诱导期。根据经典成核理论和诱导期理论 ,推导了固液表面能与诱导期的理论关系 ,应用该理论关系计算了环丙沙星在溶液中的固液表面能 ,为环丙沙星初级成核与晶体生长研究提供了重要的参数

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	刘勇
	王静康
	尹秋响

关键词：环丙沙星溶解度介稳区诱导期表面能

Abstract： The solubility,metastable zone and induction period of ciprofloaxicn hydrochloride monohydrate in water or 23% (vol) water\|ethanol solution are measured by laser method.Based on the classic nucleation theory and the induction period theory,a general expression of the relationship between the interface energy and the relative supersolubility is established.Using this expression,the interface energy of ciprofloaxicn hydrochloride monohydrate in solution at various conditions are evaluated in order to supply important parameters for studying on the primary nucleation and crystal growth.

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Received 2002-09-15; published 2002-09-15

引用本文:

刘勇,王静康,尹秋响.环丙沙星在溶液中固液表面能的测定[J]. 化学工业与工程, 2002,19(5): 354-359

LIU Yong,WANG Jing-kang,YIN Qiu-xiang .Determination the Interfacial Energy of Solid-Ligaid in Ciprofloxacin Hydrochloride Monohydrate Solution[J]. Chemcial Industry and Engineering, 2002,19(5): 354-359