Synthesis of Ethyl Nipecotate from Hydrogenation of Ethyl Nicotinate
FU Xue-jing1, FENG Ya-qing1, ZHOU Dan1,YANG Yun2(1.School of Chemical Engineering, Tianjin Unviersity, Tianjin 300072, China; 2.Shangbaizuo Country Government, Jiefang District, Jiaozuo City, Henan Province, Henan Jiaozuo 454100, China)
(1.School of Chemical Engineering, Tianjin Unviersity, Tianjin 300072, China; 2.Shangbaizuo Country Government, Jiefang District, Jiaozuo City, Henan Province, Henan Jiaozuo 454100, China
Abstract��
Ethyl nipecotate is prepared from ethyl nicotinate by hydrogenation in presence of Pd/C catalyst.The yield of ethyl nipecotate is above 70% after 12 h reaction in autoclave when acetic acid is used as solvent and 10% Pd/C catalyst is added.The synthesized products are analysed by combined means of gas chromatography-mass spectrometry.The main effect of the reaction is identified and nonpolar solvent is appropriate for the reaction.
FU Xue-jing1, FENG Ya-qing1, ZHOU Dan1,YANG Yun2.Synthesis of Ethyl Nipecotate from Hydrogenation of Ethyl Nicotinate[J]. Chemcial Industry and Engineering, 2005,22(5): 350-353
2005, Vol. 22 
