β-DDB衍生物的合成

摘要以没食子酸为原料,通过Ullmann偶合反应、烷基化、酰基化等9步反应合成了7种-βDDB的衍生物,其结构经1HNMR确认。这是一条合成-βDDB的新路线,通过与中间体6,6′-二羟基-4,5,4′,5′-二次甲二氧基-2,2′-二甲氧羰基联苯[图1(1c)]反应可以合成出不同水溶性和脂溶性的β-DDB衍生物,用于开发新型抗癌药物及保肝药物。

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	赵联娟
	王雷
	常俊标

关键词： Ullmann偶合反应联苯结构 β-DDB衍生物

Abstract： Seven new β-DDB derivatives were prepared from gallic acid in 9 steps such as Ullmann coupling reaction,alkylation,benzoylation etc.The structures of these compounds were identified by(()~1HNMR.) This is a new route to the synthesis of β-DDB.A series of β-DDB derivatives with different water-solubility and fat-solubility can be synthesized by reacting with the intermediate for the purpose of finding new antihepatotoxic and anticancer drugs.

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Received 2006-03-15; published 2006-03-15

引用本文:

赵联娟;王雷;常俊标;.β-DDB衍生物的合成[J]. 化学工业与工程, 2006,23(2): 98-101

ZHAO Lian-juan,WANG Lei,CHANG Jun-biao.Synthesis of β-DDB Derivatives[J]. Chemcial Industry and Engineering, 2006,23(2): 98-101