��޵��B��ĺϳ�

ժҪ �Զ��(SOCl2)Ϊ�߻��,ͨ��޵��B��Ӧ�ϳ��޵��B��ʵ��,��ò��ɫ�׶Է�Ӧ��и��,�о��˷�Ӧ�¶Ⱥͷ�Ӧʱ��ض��޵��B��ٶȺ�ת��ʵ�Ӱ��,ȷ��˽ϼѵķ�Ӧ��:�߻��ΪSOCl2,��Ӧ�¶�Ϊ70�桢��Ӧʱ��Ϊ7 h��,չ��ΪC2H5OH/CH2Cl2=2��1(��)��˷��ϳɡ��ᴿ��޵��B��Ĵ��ȴﵽ98.2%,��ʴﵽ83%��

	Service

	�ѱ��Ƽ��
	��ҵ��
	��ù��
	Email Alert
	RSS
	��
	��
	�ζ��
	��ϲ��
	�շ��
	��

�ؼ���� ޵��B ��

Abstract�� Isopropylrhodamine B was obtained from esterification of Rhodamine B and isopropyl alcohol,in the presence of sulfinyl chloride(SOCl_2).The reaction is monitored by thin layer chromatography(TLC).The effect of reaction temperature and time on the esterification rate and conversion rate of Rhodamine B were examined.The suitable reaction condition was SOCl_2 as catalyst,reaction temperature of 70 �� for 7 h.The isopropylrhodamine B was dissolved in dichloromethane and purified by column chromatography(ethanol/dichloromethane=2��1(volume)).In this method,the result showed that the purity of isopropylrhodamine B was 98.2% and the overall conversion rate was 83%.

Keywords��

Received 2006-05-15; published 2006-05-15

��ñ��:

��;�ζ��;��ϲ��;�շ��;��;.��޵��B��ĺϳ�[J]. ��ѧ��ҵ�빤��, 2006,23(3): 247-249

WANG Bao-he~1,DUAN Er-hong~1,YAN Xi-long~2,YAN Fan-yong~2,CHEN Li-gong~2.Synthesis of Isopropylrhodamine B[J]. Chemcial Industry and Engineering, 2006,23(3): 247-249

[1]	MACIEJ ADAMCZYK,JONATHAN GROTE.Efficientsynthesis of rhodamine conjugates through the 2-��position[J].Bioorganic Medicinal Chem Lett.2000,10:1-
[2]	JOSE J B FERREIRA,SILVIA M B COSTA.Solvent effectson the vibronic structure of S1��S0 transition of Rhodamine3B[J].Molecular Structure.2001,565/566:35-38
[3]	��Ψ,��.�޵��Ⱦ��ȡ��Ⱦ�ϸ��޺��ȶ��Ե�Ӱ��[J].��ѧ,1989,17(4):289-293.
[4]	SNEZANA MILJANTC,ZVJEZDANA CIMERMAN,LEOFRKANEC,et al.Lipophilic derivative of rhodamine 19:Characterization and spectroscopic properties[J].AnalyticaChimica Acta,2002,468:13-25.
[5]	LOUIS GABOURY,LUV VIUENEUVE,RICHARDGIASSON,et al.Novel rhodamine derivatives forphotodynamic therapy of cancer and in vitro purging of theleukemias[P].US:5 556 992,1996-9-17.
[6]	LOUIS GABOURY,LUV VIUENEUVE,RICHARDGIASSON,et al.Rhodamine derivatives for photodynamictherapy of cancer and in vitro purging of the leukemias[P].US:5 773 460,1998-6-30.
[7]	HABI ABDELKRIM,GRAVEL DENIS,VILLENEUVELAC,et al.Halogenated rhodamine derivatives andapplications thereof[P].WO:02/079183A1,2002-10-10.
[8]	LOPEI ARBELOA T,LOPEZ ARBELOA F,LOPEZARBELOA I,et al.Photophysical and lasing properties of anew ester derivatives of rhodamine 6G[J].J Luminescence.1997,75:309-317
[9]	COSTELA A,GARCIA-MORENO I,FIGUERA J M,et al.Solid-state dye lasers based on methacrylic monomers[J].JAppl Phys,1996,80(6):3 167-3 173.