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化学工业与工程
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��ѧ��ҵ�빤�� 2009, Vol. 26 Issue (2) :169-175    DOI:
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������ҩ��Discodermolide���о���չ
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Progress of Anti-Cancer Drug of Discodermolide
LI Jie~1,SHA Yong-juan~2,LI Yan-ni~3(1.Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;2.Yantai Seventh Middle School,Shandong Province,Yantai 264000,China;3.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)
(1.Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;2.Yantai Seventh Middle School,Shandong Province,Yantai 264000,China;3.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

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ժҪ Discodermolide��һ�����Ժ������ﺣ��Discodermia dissoluta�Ķ��ǻ�-��-�����໯�������ɼ������,DiscodermolideҲ�����ȶ�΢�ܵ�����,�������ڦ�-΢�ܵ����ϵĽ��λ������ɼ���ص�����������ɼ����ͬ����,Discodermolide��ˮ���Ժ�,������ǿ,�������Կ���ɼ����ϸ����Ȼ���л���,��˿��ܳ�ΪDZ�ڵĿ���ҩ��,��������������о��ߵĹ�ע����Discodermolide�ĺϳ��о������û��ơ�ģ���о���Ӧ��ǰ�����������������
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�ؼ����� Discodermolide   ��ɼ��   ΢��   ����ҩ��     
Abstract�� Discodermolide a multiple-hydroxyl-��-lactone compound,is isolated from marine sponge discodermia dissolute.Similar to paclitaxel,discodermolide is also a microtubule-stabilizing agent and shares an overlapping ��tubulin binding site with paclitaxel.However,discodermolide is better water-resolvable and more potent than paclitaxel,and it is also active in taxol-resistant cell lines.So discodermolide is determined to be a potential anticancer-drug and attracts many researchers' attention.Based on the references in recent years,the mechanism of action,synthesis,biological activity,modeling study and the application prospect of discodermolide are reviewed in this paper.
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Received 2009-03-15; published 2009-03-15
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���;ɳ����;������;.������ҩ��Discodermolide���о���չ[J].  ��ѧ��ҵ�빤��, 2009,26(2): 169-175
LI Jie~1,SHA Yong-juan~2,LI Yan-ni~3.Progress of Anti-Cancer Drug of Discodermolide[J].  Chemcial Industry and Engineering, 2009,26(2): 169-175
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