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ժҪ ��CDCl3Ϊ�ܼ�,TMSΪ�ڱ�,��ҩƷ��ε��Ʒ��NMR�ⶨ,��1H1-H COSY��HMQC��HMBC��NOESY��о��NOESYȷ֤��22(R)��22(S)�Ĺ��͡��˸�ҩƷ��ݡ�

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Abstract�� The NMR spectrums of Ciclosonide were measured and completely assigned by using CDCl_3 and TMS as the solvent and the internal standard respectively in this paper.()~1H-()~1H COSY,HMQC,HMBC,NOESY were determined.The absolute configuration of 22(R) and 22(S) carbon were confirmed by NOESY.The assignment data were in good agreement with the reported NMR spectrums of 22(R) and 22(S) budesonide-21-acetate.

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Received 2009-03-15; published 2009-03-15

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�ŵ±�;��;¬��;��֮;.22(R)��22(S)��εµĽṹ��[J]. ��ѧ��ҵ�빤��, 2009,26(2): 150-154

ZHANG De-bin~1,CHEN Li-gong~1,LU Yan-chang~2,LIN Yang-zhi~2.Structure Analysis of 22(R)and 22(S) Ciclesonide[J]. Chemcial Industry and Engineering, 2009,26(2): 150-154