| [1] | BRINER K,DODEL R C.New approaches to rapid onsetantidepressants[J].Curr Pharm Des,1998,4(4):291-302 | | [2] | SPINKS D,SPINKS G.Serotonin reuptake inhibition:Anupdate on current research strategies[J].Curr Med Chem.2002,9(8):799-810 | | [3] | OR'US L,P REZ-SILANES S,OFICIALDEGUI A M,etal.Synthesis and molecular modeling of new 1-Aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinityat the serotonin transporter and at 5-HT1Areceptors[J].JMed Chem,2002,45(19):4 128-4 139 | | [4] | MEWSHAW R E,MEAGHER K L,ZHOU P,et al.Studies toward the discovery of the next generation ofantidepressantsPart 2:incorporating a 5-HT1Aantagonistcomponent into a class of serotonin reuptake inhibitors[J]..Bioorg Med Chem Lett.2002,12(3):307-310 | | [5] | MEWSHAW R E,MEAGHER K L,ZHOU P,et al.Studies toward the discovery of the next generation ofantidepressants.Part 2:Incorporating a 5-HT1Aantagonistcomponent into a class of serotonin reuptake inhibitors[J].JMed Chem,2004,47(15):3 823-3 842 | | [6] | GILBERT A M,COLEMAN T,KODAH J,et al.Novelaryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HTtransporter and 5-HT1Aaffinity[J].Bioorg Med Chem Lett,2004,14(21):5 281-5 284 | | [7] | EVRARD D A,ZHOU P,YI S,et al.Studies towards thenext generation of antidepressantsPart 4:Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity forthe serotonin transporter and the 5-HT1Areceptor[J]..BioorgMed Chem Lett.2005,15(4):911-914 | | [8] | ZHOU D,HARRISON B L,SHAH U,et al.Studiestoward the discovery of the next generation ofantidepressantsPart 5��3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1Areceptor and serotonintransporter affinity[J]..Bioorg Med Chem Lett.2006,16(5):1- | | [9] | TAKEUCHI K,KOHN T J,HONIGSCHMIDT N A,et al.Advances toward new antidepressants beyond SSRIs:1-aryloxy-3-piperidinyl propan-2-ols with dual 5-HT1Areceptorantagonism/SSRI activities.Part 3[J].Bioorg Med ChemLett,2003,13(22):3 939-3 942 | | [10] | ROCCO V P,SPINAZZE P G,KOHN T J,et al.Advances toward new antidepressants beyond SSRIs:1-aryloxy-3-piperidinyl-propan-2-ols with dual 5-HT1Areceptor antagonism/SSRI activities.Part 4[J].Bioorg MedChem Lett,2004,14(10):2 653-2 656 | | [11] | HEINRICH T,B TTCHER H,GERICKE R,et al.Synthesis and structure-activity relationship in a class ofindolebutylpiperazines as dual 5-HT1Areceptor agonists andserotonin reuptake inhibitors[J].J Med Chem,2004,47(19):4 684-4 692 | | [12] | HEINRICH T,BOTTCHER H,SCHIEMANN K,et al.Dual 5-HT1Aagonists and 5-HT re-uptake inhibitors bycombination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity[J].Bioorg Med Chem,2004,12(18):4 843-4 852 | | [13] | TORRADO A,LAMAS C,AGEJAS J,et al.Novelselective and potent 5-HT reuptake inhibitors with 5-HT1Dantagonist activity:chemistry and pharmacological evaluationof a series of thienopyran derivatives[J].Bioorg MedChem,2004,12(20):5 277-5 295 | | [14] | TIMMS G H,BOOT J R,BROADMORE R J,et al.SARdevelopment of a selective 5-HT1Dantagonist/serotoninreuptake inhibitor lead using rapid parallel synthesis[J].Bioorg Med Chem Lett,2004,14(10):2 469-2 472 | | [15] | TAKEUCHI H,YATSUGI S,HATANAKA K,et al.Pharmacological studies on YM992,a novel antidepressantwith selective serotonin re-uptake inhibitory and 5-HT2Areceptor antagonistic activity[J].Eur J Pharmacol.1997,329(1):27-35 | | [16] | PULLAR I A,CARNEY S L,COLVIN E M,et al.LY367265,an inhibitor of the 5-hydroxytryptaminetransporter and 5-hydroxytryptamine2A receptor antagonist:acomparison with the antidepressant,nefazodone[J].Eur JPharm.2000,407(1-2):39-46 | | [17] | PULLAR I A,BOOT J R,CARNEY S L,et al.In vitroactivity of LY393558,an inhibitor of the 5-hydroxytryptamine transporter with 5-HT1B/1D/2receptorantagonist properties[J].Eur J Pharmacol.2001,432(1):9-17 | | [18] | MEYER M D,HANCOCK A A,TIETJE K,et al.Synthesis and pharmacological characterization of A-80426:A putative novel antidepressant combining-��2 antagonismwith 5-HT uptake inhibition[J].Bioorg Med Chem Lett,1995,5(19):2 287-2 292 | | [19] | MEYER M D,HANCOCK A A,TIETJE K,et al.Structure-activity studies for a novel series of N-(Arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5-HT uptake inhibiting and��2-Antagonistic activities[J].J Med Chem.1997,40(7):1- | | [20] | ANDRES J I,ALCAZAR J,ALONSO J M,et al.Synthesisof 3a,4-dihydro-3H-[1]-benzopyrano[4,3-c]isoxazoles,displaying combined 5-HT uptake inhibiting and��2-adrenoceptor antagonistic activities:A novel series ofpotential antidepressants[J].Bioorg Med Chem Lett,2003,13(16):2 719-2 725 | | [21] | ANDR S J I,ALCAZAR J,ALONSO J M,et al.Discovery of a new series of centrally active tricyclicisoxazoles combining serotonin(5-HT)reuptake inhibitionwith2��-Adrenoceptor blocking activity[J].J Med Chem,2005,48(6):2 054-2 071 | | [22] | RYCKMANS T,BALANCON L,BERTON O,et al.Firstdual NK1antagonists-serotonin reuptake inhibitors:synthesisand SAR of a new class of potential antidepressants[J].Bioorg Med Chem Lett.2002,12(2):261-264 | | [23] | RYCKMANS T,BERTON O,GRIMEE R,et al.DualNK1antagonists-serotonin reuptake inhibitors as potentialantidepressants.Part 2:SAR and activity ofbenzyloxyphenethyl piperazine derivatives[J].Bioorg MedChem Lett,2002,12(21):3 195-3 198 | | [24] | ORJALES A,MOSQUERA R,TOLEDO A,et al.Syntheses and binding studies of new[(Aryl)(aryloxy)methyl]piperidine derivatives and related compounds aspotential antidepressant drugs with high affinity for serotonin(5-HT)and norepinephrine(NE)transporters[J].J MedChem,2003,46(25):5 512-5 532 | | [25] | BOOT J R,BRACE G,DELATOUR C L,et al.Benzothienyloxy phenylpropanamines,novel dual inhibitorsof serotonin and norepinephrine reuptake[J].Bioorg MedChem Lett,2004,14(21):5 395-5 399 | | [26] | BOOT J,CASES M,CLARK B P,et al.Discovery andstructure-activity relationships of novel selectivenorepinephrine and dual serotonin/norepinephrine reuptakeinhibitors[J].Bioorg Med Chem Lett.2005,15(3):699-703 | | [27] | MILLAN M J,GOBERT A,LEJEUNE F,et al.S33005,anovel ligand at both serotonin and norepinephrinetransporters:II.behavioral profile in comparison withvenlafaxine,reboxetine,citalopram,and clomipramine[J].J Pharmacol Exp Ther,2001,298(2):581-591 | | [28] | ZHANG A,ZHOU G,RONG S,et al.Thiophenederivatives:a new series of potent norepinephrine andserotonin reuptake inhibitors[J].Bioorg Med Chem Lett.2002,12(7):993-995 | | [29] | WANG X,LIU D,LI A.1-[2-(2-Methoxyphenylthio)benzyl]-4-arylpiperazines derivatives:Synthesis andevaluation for dual 5-HT1A/SSRI activities[J].Chin ChemLett,2008,19(1):37-39 | | [30] | WANG X,LIU D,LI A.1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols:Synthesisand evaluation for dual 5-HT1A/SSRI activities[J].ChinChem Lett,2008,19(1):40-42 | | [31] | WU X,LIU D,LI A,et al.Arylpiperazine derivatives ofdiphenylsulfide:Synthesis and evaluation for dual 5-HT1A/SSRI activities[J].Chin Chem Lett.2008,19(3):291-294 | | [32] | WU X,LIU D,LI A,et al.N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation fordual 5-HT1A/SSRI activities[J].Chin Chem Lett.2008,19(3):295-298 | | [33] | LI A,ZHANG X,LIU D,et al.New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]-thiophen-3-yl)-2-methylpropanol derivatives:Synthesis and evaluation for dual 5-HT1A/SSRI activities[J].Chin Chem Lett.2008,19(4):412-414 |
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2009, Vol. 26 
