基于实验设计的<em>L</em>-谷氨酸连续结晶过程优化

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摘要对于采用连续振荡挡板式结晶器进行β型L-谷氨酸的冷却结晶，提出一种基于实验设计的晶体产品尺寸分布预测模型和过程操作条件优化方法。将连续管式结晶器的振荡频率、2个区段的降温速率作为操作变量，设计一个包含3因素3水平的响应面实验方案。通过检测不同实验条件下的晶体产品弦长分布，构建一个基于双层基函数的晶体产品尺寸分布预测模型。然后引入一个关于目标晶体尺寸分布和产品收率的目标函数，并且利用上述预测模型，建立一个优化过程操作条件的方法。通过对β型L-谷氨酸冷却结晶过程的仿真和实验，验证了该方法的有效性和优点。

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	赵洺延
	杨思维
	刘涛
	于海晨

关键词： L-谷氨酸冷却结晶实验设计晶体尺寸分布过程优化连续振荡挡板式结晶器

Abstract： For using the continuous oscillatory baffled crystallizer (COBC) to conduct cooling crystallization of β form L-glutamic acid (LGA), a prediction model of product crystal size distribution (CSD) and optimization method of process operation conditions is proposed, based on the design of experiments. The oscillation frequency and cooling rate of two zones of the COBC are taken as the operation conditions to design a 3-factor and 3-level Box-Behnken experimental scheme. By measuring the chord length distribution (CLD) of crystal products under different experimental conditions, a prediction model of the product CSD is constructed based on double-layer basis functions. Then an objective function related to the target CSD and product yield is introduced to establish an optimization method of the process operation conditions, based on the above prediction model. The effectiveness and advantages of the proposed method are verified by simulation and experiments on the cooling crystallization process of β form LGA.

Keywords： cooling crystallization of L-glutamic acid design of experiments crystal size distribution process optimization continuous oscillatory baffled crystallizer

Received 2022-07-15;

Fund:国家自然科学基金面上项目（62173058）；兴辽英才计划项目（XLYC1902030）；教育部重点实验室基金项目（DUT21LAB113）。

Corresponding Authors: 刘涛,教授,E-mail:tliu@dlut.edu.cn;于海晨,副教授,E-mail:yhc@dlut.edu.cn。 Email: tliu@dlut.edu.cn;yhc@dlut.edu.cn

About author: 赵洺延(1998-),男,硕士研究生,现从事结晶过程建模与控制方面的研究;杨思维(1998-),男,硕士研究生,现从事结晶过程建模与控制方面的研究。

引用本文:

赵洺延, 杨思维, 刘涛, 于海晨.基于实验设计的L-谷氨酸连续结晶过程优化[J]. 化学工业与工程, 2023,40(1): 53-59

ZHAO Mingyan, YANG Siwei, LIU Tao, YU Haichen.Process optimization based on the design of experiments for continuous crystallization of L-glutamic acid[J]. Chemcial Industry and Engineering, 2023,40(1): 53-59

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